Review





Similar Products

sp 600125  (MedChemExpress)
98
MedChemExpress sp 600125
Sp 600125, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sp+600125/pm41760660-410-11-12?v=MedChemExpress
Average 98 stars, based on 1 article reviews
sp 600125 - by Bioz Stars, 2026-08
98/100 stars
  Buy from Supplier
sp600125  (Tocris)
95
Tocris sp600125
Sp600125, supplied by Tocris, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sp+600125/pm41881976-250-0-10?v=Tocris
Average 95 stars, based on 1 article reviews
sp600125 - by Bioz Stars, 2026-08
95/100 stars
  Buy from Supplier
pd98059  (Tocris)
95
Tocris pd98059
a GO enrichment analysis of chondrocytes transfected with siPkm2. b Representative immunoblots and c densitometric quantification of MAPKs in IL-1β-stimulated chondrocytes isolated from Pkm2 fl/fl and Pkm2 icKO mice in the presence of 4-OHT. d Representative immunoblots and e densitometric quantification in IL-1β-stimulated chondrocytes treated with vehicle or TEPP-46 (10 and 50 μM). f Representative immunoblots and g densitometric quantification of MFN1 and MFN2 in IL-1β-stimulated chondrocytes incubated with JNK inhibitor SP600125 (20 μM), p38 inhibitor SB203580 (10 μM) or ERK inhibitor <t>PD98059</t> (10 μM). h Relative MFN1 and i MFN2 mRNA expression in IL-1β-stimulated Pkm2 fl/fl and Pkm2 icKO chondrocytes treated with vehicle, TEPP-46 (50 μM) or PD98059 (10 μM) in the presence of 4-OHT. j Representative Co-IP immunoblots of PKM2 and ERK in IL-1β-stimulated Pkm2 fl/fl and Pkm2 icKO chondrocytes treated with vehicle or TEPP-46 (50 μM) in the presence of 4-OHT. IP Immunoprecipitation, IB Immunoblotting. Data were presented as means ± s.e.m., n = 3, one-way ANOVA with Dunnett’s comparisons. * P < 0.05, ** P < 0.01.
Pd98059, supplied by Tocris, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sp+600125/pmc13039331-254-5-10?v=Tocris
Average 95 stars, based on 1 article reviews
pd98059 - by Bioz Stars, 2026-08
95/100 stars
  Buy from Supplier
jnk inhibitors include sp600125  (Tocris)
95
Tocris jnk inhibitors include sp600125
a GO enrichment analysis of chondrocytes transfected with siPkm2. b Representative immunoblots and c densitometric quantification of MAPKs in IL-1β-stimulated chondrocytes isolated from Pkm2 fl/fl and Pkm2 icKO mice in the presence of 4-OHT. d Representative immunoblots and e densitometric quantification in IL-1β-stimulated chondrocytes treated with vehicle or TEPP-46 (10 and 50 μM). f Representative immunoblots and g densitometric quantification of MFN1 and MFN2 in IL-1β-stimulated chondrocytes incubated with JNK inhibitor SP600125 (20 μM), p38 inhibitor SB203580 (10 μM) or ERK inhibitor <t>PD98059</t> (10 μM). h Relative MFN1 and i MFN2 mRNA expression in IL-1β-stimulated Pkm2 fl/fl and Pkm2 icKO chondrocytes treated with vehicle, TEPP-46 (50 μM) or PD98059 (10 μM) in the presence of 4-OHT. j Representative Co-IP immunoblots of PKM2 and ERK in IL-1β-stimulated Pkm2 fl/fl and Pkm2 icKO chondrocytes treated with vehicle or TEPP-46 (50 μM) in the presence of 4-OHT. IP Immunoprecipitation, IB Immunoblotting. Data were presented as means ± s.e.m., n = 3, one-way ANOVA with Dunnett’s comparisons. * P < 0.05, ** P < 0.01.
Jnk Inhibitors Include Sp600125, supplied by Tocris, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sp+600125/us12570957-1078-3-7?v=Tocris
Average 95 stars, based on 1 article reviews
jnk inhibitors include sp600125 - by Bioz Stars, 2026-08
95/100 stars
  Buy from Supplier

Image Search Results


a GO enrichment analysis of chondrocytes transfected with siPkm2. b Representative immunoblots and c densitometric quantification of MAPKs in IL-1β-stimulated chondrocytes isolated from Pkm2 fl/fl and Pkm2 icKO mice in the presence of 4-OHT. d Representative immunoblots and e densitometric quantification in IL-1β-stimulated chondrocytes treated with vehicle or TEPP-46 (10 and 50 μM). f Representative immunoblots and g densitometric quantification of MFN1 and MFN2 in IL-1β-stimulated chondrocytes incubated with JNK inhibitor SP600125 (20 μM), p38 inhibitor SB203580 (10 μM) or ERK inhibitor PD98059 (10 μM). h Relative MFN1 and i MFN2 mRNA expression in IL-1β-stimulated Pkm2 fl/fl and Pkm2 icKO chondrocytes treated with vehicle, TEPP-46 (50 μM) or PD98059 (10 μM) in the presence of 4-OHT. j Representative Co-IP immunoblots of PKM2 and ERK in IL-1β-stimulated Pkm2 fl/fl and Pkm2 icKO chondrocytes treated with vehicle or TEPP-46 (50 μM) in the presence of 4-OHT. IP Immunoprecipitation, IB Immunoblotting. Data were presented as means ± s.e.m., n = 3, one-way ANOVA with Dunnett’s comparisons. * P < 0.05, ** P < 0.01.

Journal: Cell Death & Disease

Article Title: Dimeric PKM2 in chondrocytes impairs mitochondrial homeostasis in osteoarthritis

doi: 10.1038/s41419-026-08621-4

Figure Lengend Snippet: a GO enrichment analysis of chondrocytes transfected with siPkm2. b Representative immunoblots and c densitometric quantification of MAPKs in IL-1β-stimulated chondrocytes isolated from Pkm2 fl/fl and Pkm2 icKO mice in the presence of 4-OHT. d Representative immunoblots and e densitometric quantification in IL-1β-stimulated chondrocytes treated with vehicle or TEPP-46 (10 and 50 μM). f Representative immunoblots and g densitometric quantification of MFN1 and MFN2 in IL-1β-stimulated chondrocytes incubated with JNK inhibitor SP600125 (20 μM), p38 inhibitor SB203580 (10 μM) or ERK inhibitor PD98059 (10 μM). h Relative MFN1 and i MFN2 mRNA expression in IL-1β-stimulated Pkm2 fl/fl and Pkm2 icKO chondrocytes treated with vehicle, TEPP-46 (50 μM) or PD98059 (10 μM) in the presence of 4-OHT. j Representative Co-IP immunoblots of PKM2 and ERK in IL-1β-stimulated Pkm2 fl/fl and Pkm2 icKO chondrocytes treated with vehicle or TEPP-46 (50 μM) in the presence of 4-OHT. IP Immunoprecipitation, IB Immunoblotting. Data were presented as means ± s.e.m., n = 3, one-way ANOVA with Dunnett’s comparisons. * P < 0.05, ** P < 0.01.

Article Snippet: SP600125 (#1496), SB203580 (#1202), and PD98059 (#1213) were purchased from Tocris (Bristol, UK).

Techniques: Transfection, Western Blot, Isolation, Incubation, Expressing, Co-Immunoprecipitation Assay, Immunoprecipitation